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Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes established that patients had a normal weight loss of four.1% in contrast to participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at one full year. Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight loss and the people that go through it you ought to err on the side of caution and allow the FDA do its job and demand some study be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their own medications. Researchers found out that participants taking this drug for a year, dropped a few pounds within one month and have kept the body weight off throughout the 56 weeks of the study. Contrave is really a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more efficient and safer. Combo-pilling will be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular is the fact that since right now there aren't any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure level and heart rate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. 
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